Similarly, topiramate half-life was longer (13%) in the elderly. It is based on topiramate (the active ingredients of Topiramate) and Topiramate (the brand name). Why? Topiramate is a medication used in the management and treatment of epilepsy and migraine. Topamax is systemic, meaning it doesn’t just act on a particular type of neurons but all neurons. Sacks et al. Topiramate was well tolerated with mild or moderate side effects, predominantly related to the central nervous system. Cramer JA, Ben Menachem E, French J. Topamax may cause brain function slowing. Dosage of drugs is not considered in the study. The mean dose of topiramate was 50 mg/day (SD = 27.4). Topiramate (brand name Topamax) is an anticonvulsant medication commonly prescribed for prophylaxis against migraine and epileptic seizures. Topamax is a voltage dependent calcium channel blocker (also called voltage-gated calcium channel blocker), which is a key channel for neuron communication via neurotransmitter release. The study uses data from the FDA. The cornerstones of treatment for obesity, and even more so for simple overweight, are dietary measures and physical exercise. generic drugs) are not considered. A fixed-dose combination of topiramate, an antiepileptic drug, and phentermine, an appetite-suppre … The most important advice is a “start low, go slow” approach. Neurology 1999 Apr 22;52(7):1330-7. If untreated, this eye problem can lead to permanent blindness. Epilepsiu, 41(Suppl.I):S61-S65, 2000 Lippincott Williams & Wilkins, Philadelphia 0 International League Against Epilepsy Clinical Pharmacology of Topiramate: A Review William R. Garnett Department of Pharmacy, School of Pharmacy, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, Virginia, U.S.A. Summary: Clinical success with an antiepileptic drug (AED) Practical tips are provided that may increase the chance that topiramate will be effective and well tolerated. Topiramate clearance is decreased in the elderly only to the extent that renal function is … METHODS This was a retrospective study. It is in the second-generation anti-epileptic drugs class of medications. PMID: 10227614. OBJECTIVE To explore the impact of topiramate on tests of intellect and other cognitive processes. Reduced topiramate clearance resulted in slightly higher maximum plasma concentration (23%) and AUC (25%) in elderly subjects than observed in young adults. Rarely, topiramate may cause a very serious eye problem, generally within 1 month of starting treatment. There are no drugs with a favourable harm-benefit balance in this setting. Review of treatment options for refractory epilepsy: new medications and vagal nerve stimulation. treated 14 patients with treatment resistant bipolar disorder and a variety of co-morbid conditions for a mean of 22.4 +/- 22.0 weeks with adjunctive topiramate in a retrospective trial. Other drugs that have the same active ingredients (e.g. Topamax was effective as add-on therapy for primary generalized seizures in both adults and children, and side effects were not a serious problem.
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